Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage
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چکیده
Cerebral Vasospasm Induced − Endothelin B Receptor Antagonists Attenuate Subarachnoid Hemorrhage Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.29.9.1924 1998;29:1924-1929 Stroke. http://stroke.ahajournals.org/content/29/9/1924 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Endothelin receptor antagonists for aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update.
BACKGROUND AND PURPOSE Endothelin is considered to be a key mediator of vasospasm after subarachnoid hemorrhage. A meta-analysis of randomized trials on the effectiveness of endothelin receptor antagonists in subarachnoid hemorrhage has been published previously, but since then new major trials have been published. We present the results of a systematic review and meta-analysis update. METHOD...
متن کاملEndothelin B receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm.
BACKGROUND AND PURPOSE While it has been widely reported that the vasospasm following subarachnoid hemorrhage (SAH) is prevented/reversed by endothelin (ET) receptor antagonists selective for the ET(A) receptor and by nonselective ET receptor antagonists, ie, antagonists of both the ET(A) and ET(B) receptors, there are no reports on the possible attenuation of the spasm by selective ET(B) recep...
متن کاملEndothelin antagonists in subarachnoid hemorrhage: what next?
In the previous issue of Critical Care, Ma and colleagues perform a meta-analysis of five randomized, clinical trials of endothelin antagonists in patients with aneurysmal subarachnoid hemorrhage. There are four trials using clazosentan and one trial with TAK-044. These studies show that endothelin plays an important role in the genesis of angiographic vasospasm. The benefit of these drugs is l...
متن کاملDissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan.
BACKGROUND AND PURPOSE Endothelin receptor antagonists such as clazosentan decrease large-artery vasospasm after experimental and clinical subarachnoid hemorrhage. We used clazosentan to gain insight into the pathophysiology of subarachnoid hemorrhage by determining if decreasing vasospasm is associated with alleviation of other secondary complications of subarachnoid hemorrhage such as oxidati...
متن کاملDo endothelin-receptor antagonists prevent delayed neurological deficits and poor outcomes after aneurysmal subarachnoid hemorrhage?: a meta-analysis.
BACKGROUND AND PURPOSE Delayed ischemic neurological deficits (DINDs) contribute to poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). Endothelin-1 is an important mediator involved in the development of vasospasm. METHODS We performed a systematic review and meta-analysis of randomized controlled trials assessing the use of endothelin-receptor antagonists (ETRAs) in patients with ...
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